Maleate salts of bedaquiline
نویسندگان
چکیده
منابع مشابه
A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment.
tuberculosis prevention, care and control after 2015. Geneva, WHO, 2014. 13 World Health Organization. Definitions and reporting framework for tuberculosis – 2013 revision. Geneva, WHO, 2013. 14 Van Deun A, Maug AK, Bola V, et al. Rifampicin drug resistance tests for tuberculosis: challenging the gold standard. J Clin Microbiol 2013; 51: 2633–2640. 15 Salje H, Andrews JR, Deo S, et al. The impo...
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THE TITLE COMPOUND [SYSTEMATIC NAME: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethyl-propan-1-aminium hydrogen maleate], C(20)H(27)N(2) (+)·C(4)H(3)O(4) (-), a maleate salt of trimipramine, crystallizes with four independent cation-anion pairs in the asymmetric unit. The trimipramine cation contains a seven-membered azepine ring with two fused benzene rings whose mean planes are se...
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Mol-ecules in the title compound, C(4)H(7)N(2) (+)·C(4)H(3)O(4) (-), are linked by inter-molecular N-H⋯O hydrogen bonds into one-dimensional chains parallel to [101]. These chains are in turn linked by an R(2) (2)(8) motif, formed by weak C-H⋯O hydrogen bonds, into corrugated sheets running parallel to (10). These sheets are further linked by weak inter-molecular C-H⋯O hydrogen bonds, forming a...
متن کاملAcquired Resistance of Mycobacterium tuberculosis to Bedaquiline
Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multi-drug resistant tuberculosis in decades. In vitro resistance to BDQ was previously shown to be due to target-based mutations. Here we report that non-target based resistance to BDQ, and cross-resistance to clofazimine (CFZ), is due to mutations in Rv0678, a transcriptional repressor of the genes...
متن کاملThe Effects of Ergonovine Maleate
Changes in coronary arterial size due to ergonovine maleate are described and quantitated in 90 patients 18 with typical angina pectoris, 56 with atypical chest pain, nine with variant angina pectoris, and seven heart transplant (allograft) recipients. We observed two angiographic changes in the diameter of coronary arteries: 1) spasm, which was characterized by occlusion or marked (>85%) focal...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Crystallographic Communications
سال: 2021
ISSN: 2056-9890
DOI: 10.1107/s2056989021002991